Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle.

@article{Nez2005InhibitoryEO,
  title={Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle.},
  author={V. Teigeiro N{\'u}{\~n}ez and Victor Gonzalez Castro and R Jes{\'u}s Elides Murillo and Luis Alberto Ponce-Soto and Irmgard Merfort and Bruno Lomonte},
  journal={Phytochemistry},
  year={2005},
  volume={66 9},
  pages={
          1017-25
        }
}
Phospholipases A(2) (PLA(2)) are important constituents of snake venoms, being responsible for several of their toxic actions. Extracts from plants used in folk medicine were screened for inhibition of the enzymatic activity of myotoxin I, a PLA(2) from Bothrops asper. Piper umbellatum and Piper peltatum extracts tested positive, and their fractionation resulted in the isolation of 4-nerolidylcatechol. Its inhibitory effects towards toxic activities of two Bothrops myotoxins, representing… CONTINUE READING
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