• Corpus ID: 44900398

Inhibitory effects of IFN-gamma on HIV-1 replication in latently infected cells.

  title={Inhibitory effects of IFN-gamma on HIV-1 replication in latently infected cells.},
  author={L Sarol and Kenichi Imai and Kaori Asamitsu and Toshifumi Tetsuka and Nina G. Barzaga and Takashi Okamoto},
  journal={Biochemical and biophysical research communications},
  volume={291 4},
The progress in the use of HAART for the treatment of HIV-infected individuals has been limited by the development of viral resistance and the maintenance of viral latency. New therapeutic strategies geared toward improvement in the host's immune response are now being considered. We found that IFN-gamma induces CIITA through the JAK-STAT pathway and inhibits HIV-1 replication in latently infected cells. Its effect appears to be mediated through the reciprocal action of Tat and CIITA. With this… 
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