Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase.

Abstract

Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, we conclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agents with inhibitory effects in addition to their antioxidant properties.

Extracted Key Phrases

5 Figures and Tables

Statistics

050100200920102011201220132014201520162017
Citations per Year

220 Citations

Semantic Scholar estimates that this publication has 220 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Gao2007InhibitoryEO, title={Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase.}, author={Hong Gao and Jun Nishida and Shizuka Saito and Jun Kawabata}, journal={Molecules}, year={2007}, volume={12 1}, pages={86-97} }