• Corpus ID: 24310912

Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.

@article{Mizushina2006InhibitoryEO,
  title={Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.},
  author={Yoshiyuki Mizushina and Kiyotaka Nakagawa and Akira Shibata and Yasutoshi Awata and Isoko Kuriyama and Noriko Shimazaki and Osamu Koiwai and Yukinobu Uchiyama and Kengo Sakaguchi and Teruo Miyazawa and Hiromi Yoshida},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={339 3},
  pages={
          949-55
        }
}
Tocotrienols, vitamin E compounds that have an unsaturated side chain with three double bonds, selectively inhibited the activity of mammalian DNA polymerase lambda (pol lambda) in vitro. These compounds did not influence the activities of replicative pols such as alpha, delta, and epsilon, or even the activity of pol beta which is thought to have a very similar three-dimensional structure to the pol beta-like region of pol lambda. Since delta-tocotrienol had the strongest inhibitory effect… 
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