Inhibitory effect of the antimalarial agent artesunate on collagen-induced arthritis in rats through nuclear factor kappa B and mitogen-activated protein kinase signaling pathway.

@article{Li2013InhibitoryEO,
  title={Inhibitory effect of the antimalarial agent artesunate on collagen-induced arthritis in rats through nuclear factor kappa B and mitogen-activated protein kinase signaling pathway.},
  author={Yan-Mei Li and Shaogui Wang and Ying Wang and Chun Zhou and Guangxing Chen and Weixing Shen and Cuixian Li and Wei Ju Lin and Sisi Lin and Heqing Huang and Peiqing Liu and Xiaoyan Shen},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2013},
  volume={161 2},
  pages={
          89-98
        }
}
Recent evidence indicates that the antimalarial agent artesunate (ART) has immunomodulatory properties that may be useful for treating rheumatoid arthritis (RA). However, the effects of ART on the RA animal model have not been described. The current study aimed to evaluate the antiarthritic effect of ART and explore the potential mechanism on type II collagen-induced arthritis (CIA) in rats. From the day of arthritis onset, rats were treated daily by gavage with leflunomide (Lef) or ART at a… CONTINUE READING
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