Inhibitory effect of the Agrobacterium rhizogenes rolC gene on rabdosiin and rosmarinic acid production in Eritrichium sericeum and Lithospermum erythrorhizon transformed cell cultures

@article{Bulgakov2004InhibitoryEO,
  title={Inhibitory effect of the Agrobacterium rhizogenes rolC gene on rabdosiin and rosmarinic acid production in Eritrichium sericeum and Lithospermum erythrorhizon transformed cell cultures},
  author={Victor P. Bulgakov and Marina V Veselova and Galina K. Tchernoded and Konstantin Kiselev and Sergey A. Fedoreyev and Yu. N. Zhuravlev},
  journal={Planta},
  year={2004},
  volume={221},
  pages={471-478}
}
Rabdosiin and related caffeic acid metabolites have been proposed as active pharmacological agents demonstrating potent anti-HIV and antiallergic activities. We transformed Eritrichium sericeum and Lithospermum erythrorhizon seedlings by the rolC gene, which has been recently described as an activator of plant secondary metabolism. Surprisingly, the rolC-transformed cell cultures of both plants yielded two- to threefold less levels of rabdosiin and rosmarinic acid (RA) than respective control… CONTINUE READING
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