Inhibitory effect of tetrandrine on pulmonary metastases in CT26 colorectal adenocarcinoma-bearing BALB/c mice.

@article{Chang2004InhibitoryEO,
  title={Inhibitory effect of tetrandrine on pulmonary metastases in CT26 colorectal adenocarcinoma-bearing BALB/c mice.},
  author={K M Chang and Hui-Fen Liao and Hen-Hong Chang and Yu-Jen Chen and Ming-Chien Yu and C Chou},
  journal={The American journal of Chinese medicine},
  year={2004},
  volume={32 6},
  pages={863-72}
}
Tumor metastasis is a major cause of mortality in cancer patients. The anti-metastatic effect of tetrandrine, an alkaloid isolated from Stephania tetrandrae S. Moore, was investigated in a pulmonary metastatic model of colorectal cancer-bearing mice. Tetrandrine decreased the viability of murine colorectal adenocarcinoma CT26 cells in a time- and dose-dependent manner. CT26 cells were injected into BALB/c mice via a tail vein to establish pulmonary metastases. After this, the mice were given… CONTINUE READING