Inhibitory effect of synthetic cannabinoids on CYP1A activity in mouse liver microsomes.

@article{Ashino2014InhibitoryEO,
  title={Inhibitory effect of synthetic cannabinoids on CYP1A activity in mouse liver microsomes.},
  author={Takashi Ashino and Kanae Hakukawa and Yuka Itoh and S. Numazawa},
  journal={The Journal of toxicological sciences},
  year={2014},
  volume={39 6},
  pages={
          815-20
        }
}
Synthetic cannabinoids developed by chemical modification are believed to bind to cannabinoid receptors and cause neurological effects similar to cannabis; however, their effects on drug metabolizing enzymes are unknown. This study aimed to elucidate the effect of synthetic cannabinoids on cytochrome P450 1A activity. Naphthoylindole, a basic structure of the major synthetic cannabinoids, strongly inhibited CYP1A activity in a competitive manner; the apparent Ki value was 0.40 μM. The N… Expand
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