Inhibitory effect of shark serum on the Lewis lung carcinoma.

  title={Inhibitory effect of shark serum on the Lewis lung carcinoma.},
  author={M J Snodgrass and Jack D. Burke and Gerald D. Meetz},
  journal={Journal of the National Cancer Institute},
  volume={56 5},
The growth and metastasis of transplanted Lewis lung carcinoma in C57BL/6J mice were inhibited by an ip injection of whole serum from Carcharhinus plumbeus, the sandbar shark. Tumors failed to develop in 69% of the animals inoculated with shark serum on days 0, 3, and 6 after tumor transplantation. Histologic examination of the tumor site at days 3 and 6 showed that tumor cells were pyknotic, and evidence of lysis of tumor cells and minor leukocytic infiltration existed. Tumor cells were not in… CONTINUE READING