Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage-like cells.

@article{Cho1998InhibitoryEO,
  title={Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage-like cells.},
  author={Jaeweon Cho and Joon Seok Park and Eun Sook Yoo and Kyong Up Baik and Jee H Jung and Jae Hyeok Lee and Myung Hwan Park},
  journal={Planta medica},
  year={1998},
  volume={64 7},
  pages={594-7}
}
Total methanol extract of Saussurea lappa radix (Compositae) showed potent inhibitory effect on the production of tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, in murine macrophage-like cell (RAW264.7 cells) in our previous screening studies on 120 Korean medicinal plants. The activity-guided purification of the plant resulted in the isolation of three components. The chemical structures of the components isolated were established by spectroscopic analyses as… CONTINUE READING