Inhibitory effect of salmeterol on the respiratory burst of adherent human neutrophils.

@article{Ottonello1996InhibitoryEO,
  title={Inhibitory effect of salmeterol on the respiratory burst of adherent human neutrophils.},
  author={Luciano Carlo Ottonello and P. Morone and Patrizia Dapino and Franco Dallegri},
  journal={Clinical and experimental immunology},
  year={1996},
  volume={106 1},
  pages={97-102}
}
Human neutrophils, plated in fibronectin-coated wells and stimulated with N-formyl-methionylleucyl-phenylalanine (fMLP), were found to undergo a massive and prolonged respiratory burst, as measured by monitoring superoxide production. The beta 2-agonist salmeterol inhibited the respiratory burst in a dose-dependent manner. In contrast, salbutamol was ineffective. Moreover, the neutrophil respiratory burst was partially suppressed by prostaglandin E2 (PGE2) and the phosphodiesterase type IV (PDE… CONTINUE READING

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The inhibitory activity of salmeterol was not reversed in the presence of the beta - blocker propranolol , and did not correlate with its ability of increasing cyclic AMP ( cAMP ) levels .
The inhibitory activity of salmeterol was not reversed in the presence of the beta - blocker propranolol , and did not correlate with its ability of increasing cyclic AMP ( cAMP ) levels .
The inhibitory activity of salmeterol was not reversed in the presence of the beta - blocker propranolol , and did not correlate with its ability of increasing cyclic AMP ( cAMP ) levels .
The inhibitory activity of salmeterol was not reversed in the presence of the beta - blocker propranolol , and did not correlate with its ability of increasing cyclic AMP ( cAMP ) levels .
Human neutrophils , plated in fibronectin - coated wells and stimulated with N - formyl - methionylleucyl - phenylalanine ( fMLP ) , were found to undergo a massive and prolonged respiratory burst , as measured by monitoring superoxide production .
Human neutrophils , plated in fibronectin - coated wells and stimulated with N - formyl - methionylleucyl - phenylalanine ( fMLP ) , were found to undergo a massive and prolonged respiratory burst , as measured by monitoring superoxide production .
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