Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans

@article{Lee1991InhibitoryEO,
  title={Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans},
  author={Myung Ae Lee and J. Frank Nash and Marianne Barnes and Herbert Y Meltzer},
  journal={Psychopharmacology},
  year={1991},
  volume={103},
  pages={258-264}
}
Oral administration of the serotonin (5-HT) precursorl-5-hydroxytryptophan (5-HTP), 200 mg, significantly increased plasma cortisol levels in man.l-5-HTP had no significant effect on the plasma prolactin levels. A borderline effect of 5-HTP on plasma ACTH levels was found. Pretreatment with the 5-HT2/5-HT1C antagonist ritanserin (5 mg, PO, b.i.d. for 2 days) significantly inhibited 5-HTP-induced cortisol secretion. Ritanserin had no effect on the basal plasma cortisol or prolactin levels. These… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

5-HTlc receptor is a prominent serotonin receptor subtype in the central nervous system

  • SM Molineaux, TM JesseI, R Axel, D Julius
  • Proc Natl Acad Sci USA
  • 1989
1 Excerpt

Similar Papers

Loading similar papers…