Inhibitory effect of polyoxotungstates on the production of penicillin-binding proteins and beta-lactamase against methicillin-resistant Staphylococcus aureus.

@article{Fukuda1999InhibitoryEO,
  title={Inhibitory effect of polyoxotungstates on the production of penicillin-binding proteins and beta-lactamase against methicillin-resistant Staphylococcus aureus.},
  author={Norio Fukuda and Toshihiro Yamase and Yutaka Tajima},
  journal={Biological & pharmaceutical bulletin},
  year={1999},
  volume={22 5},
  pages={463-70}
}
In our continuous work on the enhancement of the antibacterial activity of beta-lactam antibiotics against the cells of methicillin-resistant Staphylococcus aureus (MRSA) strains by Keggin-structural polyoxotungstates and their lacunary species, Wells-Dawson, double-Keggin, and Keggin-sandwich polyoxotungstates are also found to be synergistic but highly cytotoxic. The coexistence of polylysine or protamine sulphate decreased the synergistic potency of the polyoxotungstates, due to their… CONTINUE READING
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