Inhibitory effect of obestatin on glucose-induced insulin secretion in rats.

  title={Inhibitory effect of obestatin on glucose-induced insulin secretion in rats.},
  author={An-jing Ren and Zhi-fu Guo and Yang-Kai Wang and Ligang Wang and Wei Wang and Li Lin and Xing Bang Zheng and W Yuan},
  journal={Biochemical and biophysical research communications},
  volume={369 3},
Obestatin is a bioactive peptide encoded by the same gene that encodes ghrelin. Our aim was to investigate the effect of obestatin on insulin secretion. We evaluated the effects of obestatin on insulin secretion from rat islet cells which had been incubated overnight in the presence of 8.3, 11.1, and 22.2 mmol/l of glucose. In vivo, the serum levels of glucose and insulin were measured 0, 1, 5, 10, 20, 40, and 60 min after the intravenous administration of saline or glucose (1g/kg), with or… CONTINUE READING

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