Inhibitory effect of noradrenaline uptake inhibitors on contractions of rat aortic smooth muscle

@article{Huang1996InhibitoryEO,
  title={Inhibitory effect of noradrenaline uptake inhibitors on contractions of rat aortic smooth muscle},
  author={Y. Huang},
  journal={British Journal of Pharmacology},
  year={1996},
  volume={117}
}
  • Y. Huang
  • Published 1 February 1996
  • Biology, Chemistry, Medicine
  • British Journal of Pharmacology
1 The effects of noradrenaline (NA) uptake inhibitors on contractions induced by NA, high K+, and 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) in rat isolated aorta were investigated. 2 Protriptyline (0.3 μm) and amitriptyline (0.3 μm) produced an approximately parallel shift to the right in the dose‐response curve to NA. Protriptyline (>0.3 μm), amitriptyline (>0.3 μm) and xylamine (0.01‐1 μm) significantly reduced the maximal contractile response to NA. The IC50 values for inhibition of the… 
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