Inhibitory effect of nicotinamide on in vitro and in vivo production of tumor necrosis factor-alpha.

@article{Fukuzawa1997InhibitoryEO,
  title={Inhibitory effect of nicotinamide on in vitro and in vivo production of tumor necrosis factor-alpha.},
  author={Masahiro Fukuzawa and Jo Satoh and Gen Muto and Yasutoshi Muto and Shin-Ichiro Nishimura and Shuichi Miyaguchi and Xia Qiang and Takayoshi Toyota},
  journal={Immunology letters},
  year={1997},
  volume={59 1},
  pages={7-11}
}
Nicotinamide, a pellagra-preventive factor, has multiple functions such as inhibition of poly-ADP-ribose synthetase, inhibition of inducible nitric oxide synthase, free radical scavenging and suppression of major histocompatibility complex class II expression and ICAM-1 expression on endothelial cells. In addition to these, we have found an inhibitory effect of nicotinamide on production of tumor necrosis factor-alpha (TNF-alpha) in vitro and in vivo. Lipopolysaccharide (LPS)-induced in vitro… CONTINUE READING
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