Inhibitory effect of murine recombinant IL-4 on thymocyte development in fetal thymus organ cultures.

Abstract

The effect of rIL-4 on early T cell development in fetal thymus organ culture was studied by two-color immunofluorescence and by proliferation assays. Addition of IL-4 to an organ culture of 14-day-old fetal BALB/c thymus resulted in a decreased cell yield (less than 15% as compared to the control culture) and in a complete inhibition of CD4+CD8+ thymocytes… (More)

Topics

Cite this paper

@article{Plum1990InhibitoryEO, title={Inhibitory effect of murine recombinant IL-4 on thymocyte development in fetal thymus organ cultures.}, author={Jessica L V Plum and Maryse De Smedt and Guillaume Leclercq and Brian E Tison}, journal={Journal of immunology}, year={1990}, volume={145 4}, pages={1066-73} }