Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities

  title={Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities},
  author={Nur Aziah Hanapi and Sabariah Ismail and Saleh Muhammad Mansor},
  booktitle={Pharmacognosy research},
CONTEXT To date, many findings reveal that most of the modern drugs have the ability to interact with herbal drugs. AIMS This study was conducted to determine the inhibitory effects of mitragynine on cytochrome P450 2C9, 2D6 and 3A4 activities. METHODS AND MATERIAL The in vitro study was conducted using a high-throughput luminescence assay. STATISTICAL ANALYSIS Statistical analysis was conducted using one-way ANOVA and Dunnett's test with P < 0.05 vs. control. The IC50 values were… CONTINUE READING
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