Inhibitory effect of lysophosphatidylcholine and phospholipase A2-treated low density lipoproteins on receptor-dependent regulation of {Ca2+}i in platelets.


Treatment of LDL with phospholipase A from bee venom resulted in formation of lipid-protein particles (pl2 LDL) with increased content of lysophosphatidylcholine (LPC). At the same time, composition of other lipids and protein structure were unaffected. Both pl-LDL and LPC abolished PAF-, ADP- and thrombin-induced Ca2+ elevation in platelets and platelet… (More)