Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer.

@article{Wu2007InhibitoryEO,
  title={Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer.},
  author={Wb Wu and Han-Sun Chiang and J.-Y. Fang and C F Hung},
  journal={Biochemical Society transactions},
  year={2007},
  volume={35 Pt 5},
  pages={
          1377-8
        }
}
Tumours are complex tissues composed of both matrix proteins and stromal cells such as fibroblasts and inflammatory cells. Tumour progression is often the result of dynamic interactions between the tumour cells and their surroundings. Lycopene, a natural carotenoid that is abundant in tomato, has been shown to inhibit proliferation of several types of cancer cells through arrest of tumour cell-cycle progression, IGF-1 (insulin-like growth factor 1) signalling transduction, induction of… Expand
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