Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19).

@article{Lu2012InhibitoryEO,
  title={Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19).},
  author={Dan-Feng Lu and Lijuan Yang and Fei Wang and Guo-lin Zhang},
  journal={Journal of agricultural and food chemistry},
  year={2012},
  volume={60 34},
  pages={8411-8}
}
Inhibition of aromatase, the key enzyme in estrogen biosynthesis, is an important strategy in the treatment of breast cancer. Several dietary flavonoids show aromatase inhibitory activity, but their tissue specificity and mechanism remain unclear. This study found that the dietary flavonoid luteolin potently inhibited estrogen biosynthesis in a dose- and time-dependent manner in KGN cells derived from human ovarian granulosa cells, the major source of estrogens in premenopausal women. Luteolin… CONTINUE READING

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