Inhibitory effect of gap junction blockers on cerebral vasospasm.

@article{Hong2008InhibitoryEO,
  title={Inhibitory effect of gap junction blockers on cerebral vasospasm.},
  author={Tao Hong and Yang Wang and Haitao Wang and Huan Wang},
  journal={Journal of neurosurgery},
  year={2008},
  volume={108 3},
  pages={
          551-7
        }
}
OBJECT The gap junction is important in the propagation of dilation/constriction signals along vessels for coordinated behavior in control of vascular tone. The authors hypothesized that gap junctions might play a role in cerebral vasospasm following subarachnoid hemorrhage (SAH). The aims of the present study were to investigate the role of gap junctions and to observe the potential therapeutic efficacy of gap junction blockers in cerebral vasospasm in vitro and in vivo. METHODS For the in… 
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The important role of connexin 43 in subarachnoid hemorrhage-induced cerebral vasospasm
TLDR
The current findings suggest that Cx43 and the PKC pathway are novel targets for developing treatments for SAH-induced CVS and indicate that changes in Cx 43 expression may be mediated by thePKC pathway.
Role of gap junctions in early brain injury following subarachnoid hemorrhage
Upregulation of Connexin 40 mediated by nitric oxide attenuates cerebral vasospasm after subarachnoid hemorrhage via the NO-cGMP-PKG pathway.
Cx 43 and Cx 45 heteromeric gap junction may play an important role in cerebral vasospasm due to experimental subarachnoid hemorrhage
TLDR
It is demonstrated that Cx43/Cx45 heteromeric gap junctions may play an important role in the pathogenesis of CVS after SAH, and the gap junction blocker CBX inhibited this tendency.
Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats
TLDR
Treatment with 18β-GA in SAH rats decreases Cx43 and Cx45 in basilar artery and ADMA in CSF, which is probably involved in the pathophysiological events of CVS after SAH by altering connexin proteins.
Gap junctions as therapeutic targets in brain injury following hypoxia-ischemia.
TLDR
This review focuses on the role of connexins (Cxs, transmembrane proteins that form GJ channels) in the pathophysiology of neuronal injury after brain hypoxia-ischemia, the opposing theories regarding whether Cxs are protective agents or contribute to the spread of damage.
Specific Mechanotransduction Signaling Involved in Myogenic Responses of the Cerebral Arteries
TLDR
It is emphasized that it is important to recognize mechanical forces and control them not only to improve the knowledge of cardiovascular system in physiologic and pathophysiologic conditions but also for the development of new therapeutic drugs.
The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model
TLDR
This review explores the settings and technical issues of establishing a rabbit cisterna magna single and double blood injection SAH model and discusses the characteristics and feasibilities of the models.

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