Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia.

@article{Cui2010InhibitoryEO,
  title={Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia.},
  author={Yan-qiu Cui and Li-juan Zhang and Ting Zhang and Ding-zhen Luo and Yan-jun Jia and Zi-Xuan Guo and Quan Zhang and Xuan Wang and Xiaomin Wang},
  journal={Clinical and experimental pharmacology & physiology},
  year={2010},
  volume={37 4},
  pages={
          422-8
        }
}
1. Microglial activation plays an important role in the pathogenesis of neurodegenerative diseases by producing various pro-inflammatory cytokines. Microglia-derived nitric oxide (NO) is critical for the lipopolysaccharide (LPS)-induced selective loss of dopaminergic neurons. 2. Fucoidan is a sulphated polysaccharide extracted from brown seaweeds. It has a variety of biological actions, including anticoagulant, antiviral and anti-inflammatory effects. The aim of the present study was to… CONTINUE READING
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