Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats

@article{Pivac1993InhibitoryEO,
  title={Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats},
  author={Nela Pivac and Danka Peri{\vc}i{\'c}},
  journal={Journal of Neural Transmission / General Section JNT},
  year={1993},
  volume={92},
  pages={173-186}
}
The acute intraperitoneal administration of anxiolytic diazepam (2 mg/kg) inhibits the activity of the hypothalamic-pituitary-adrenal (HPA) axis, i.e., it decreases the concentration of adrenocorticotropic hormone (ACTH) and corticosterone in female rats. This fall of ACTH and corticosterone levels was reversed by an antagonist of central benzodiazepine receptors — flumazenil. The antagonist of peripheral benzodiazepine receptors — PK 11195, failed to affect diazepam-induced decrement of plasma… CONTINUE READING

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