Inhibitory effect of corticosteroids on the secretion of tumour necrosis factor (TNF) by monocytes is dependent on the stimulus inducing TNF synthesis.

@article{Debets1989InhibitoryEO,
  title={Inhibitory effect of corticosteroids on the secretion of tumour necrosis factor (TNF) by monocytes is dependent on the stimulus inducing TNF synthesis.},
  author={Joop M H Debets and Theo Ruers and M P van der Linden and Cees J van der Linden and Wim A. Buurman},
  journal={Clinical and experimental immunology},
  year={1989},
  volume={78 2},
  pages={224-9}
}
The cytokine tumour necrosis factor (TNF) is believed to be involved in the pathophysiology of several human disease states, both septic and non-septic. Different pathways of induction are involved in the generation ofTNF in these disease states. We therefore used four different stimulatory agents, lipopolysaccharide, phorbol myristate acetate, silica quartz, and anti-human IgG antibody to study the influence of the corticosteroids prednisolone and budesonide on the secretion of TNF by human… CONTINUE READING