Inhibitory effect of breast milk on infectivity of live oral rotavirus vaccines.

  title={Inhibitory effect of breast milk on infectivity of live oral rotavirus vaccines.},
  author={S Moon and Yuhuan Wang and Andi L. Shane and Trang T.H. Nguyen and Pratima Ray and Penelope H. Dennehy and Luck Ju Baek and Umesh Parashar and Roger I. Glass and Baoming Jiang},
  journal={The Pediatric infectious disease journal},
  volume={29 10},
BACKGROUND Live oral rotavirus vaccines have been less immunogenic and efficacious among children in poor developing countries compared with middle income and industrialized countries for reasons that are not yet completely understood. We assessed whether the neutralizing activity of breast milk could lower the titer of vaccine virus and explain this difference in vitro. METHODS Breast milk samples were collected from mothers who were breast-feeding infants 4 to 29 weeks of age (ie, vaccine… CONTINUE READING
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