Inhibitory effect of bread crust antioxidant pronyl-lysine on two different categories of colonic premalignant lesions induced by 1,2-dimethylhydrazine

  title={Inhibitory effect of bread crust antioxidant pronyl-lysine on two different categories of colonic premalignant lesions induced by 1,2-dimethylhydrazine},
  author={Jayabal Panneerselvam and Selvaraj Aranganathan and Namasivayam Nalini},
  journal={European Journal of Cancer Prevention},
Colorectal malignancies continue to be one of the most frequent and life-threatening diseases throughout the world. Pronyl-lysine, a product obtained from bread crust, is a potent free radical scavenging antioxidant exerting chemopreventive activity by reducing oxidative stress. This study was conducted to investigate the effects of pronyl-lysine supplementation on the formation of colonic precancerous lesions, circulatory lipid peroxidation, and enzymic antioxidant status in 1,2… Expand
Effect of amino acids on Maillard reaction product formation and total antioxidant capacity in white pan bread
Maillard reaction products (MRPs) can be an important dietary antioxidant source. Bread is the most popular bakery product; however, limited information is available on the antioxidant activities ofExpand
The gastro-intestinal tract as the major site of biological action of dietary melanoidins
A review in which the gastro-intestinal tract is hypothesized to be the main site of action of food melanoidins and melanoproteins biological activity and recent data supporting this hypothesis both in vitro model systems and in vivo is described. Expand
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Since all the sampled bread had potassium bromate in concentration above safe level for human consumption, bread consumers and bakers are at risk of exposure to potassiumbromate with health implications. Expand
A new glycation product ‘norpronyl-lysine,’ and direct characterization of cross linking and other glycation adducts: NMR of model compounds and collagen
NMR is ideal for characterizing non-enzymatic protein glycation, including AGEs (advanced glycation endproducts) underlying tissue pathologies in diabetes and ageing. Ribose, R5P (ribose-5-phosphate)Expand
The Food Safety – Nutrition Nexus
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Cancer control and prevention in Europe: the contribution of the European Journal of Cancer Prevention.
  • J. Janssens, C. la Vecchia
  • Medicine
  • European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 2012
This research presents a novel and scalable approach called ‘SmartLabeling’ that allows for real-time assessment of the impact of environmental toxins on the development of cancer in the clinic and its consequences. Expand


Influence of feeding malt, bread crust, and a pronylated protein on the activity of chemopreventive enzymes and antioxidative defense parameters in vivo.
The main systemic effects of dietary malt, bread crust, and pronyl-BSA were demonstrated to be the enhanced antioxidant capacity and the particulate increase in chemopreventive enzymes. Expand
Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer.
  • V. Manju, N. Nalini
  • Chemistry, Medicine
  • Clinica chimica acta; international journal of clinical chemistry
  • 2005
Ginger supplementation suppresses colon carcinogenesis in the presence of the procarcinogen DMH and significantly reduced circulating lipid peroxidation and significantly enhanced the enzymic and non-enzymic antioxidants as compared to unsupplemented DMH-treated rats. Expand
Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis.
It is indicated that resveratrol effectively inhibits DMH-induced ACF and colonic tumor development and modulation of lipid peroxidation markers and antioxidants status, which were paralleled with ACF suppression, as compared toDMH-alone treated rats. Expand
Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon carcinogenesis
It is confirmed that pronyl-lysine has a positive beneficial effect against chemically induced colonic preneoplastic progression in rats, and is a key antioxidant present in bread crust. Expand
Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat.
The finding that crude alpha-mangostin has potent chemopreventive effects in the authors' short-term colon carcinogenesis bioassay system suggests that longer exposure might result in suppression of tumor development. Expand
Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development
The inhibitory effect of resveratrol is demonstrated on DMH-induced colon carcinogenesis in rats by modulating the development of aberrant crypt foci and the activities of bacterial enzymes. Expand
The modifying effect of Peucedanum japonicum, a herb in the Ryukyu Islands, on azoxymethane-induced colon preneoplastic lesions in male F344 rats.
It is indicated that PJ inhibits both ACF formation and accumulation of beta-catenin, and that PJ also reduces the cell proliferation activity, suggesting that PJ may have chemopreventive potential for colon carcinogenesis. Expand
Dietary Conjugated Linolenic Acid Inhibits Azoxymethane‐induced Colonic Aberrant Crypt Foci in Rats
CLN administration lowered the PCNA index and induced apoptosis in ACF, suggesting possible chemopreventive activity of CLN in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis. Expand
Increased induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats fed diets containing purified genistein or genistein-rich soya protein.
It is concluded that genistein has no detectable effect on colonic crypt mitosis or apoptosis in the rat in vivo, but that it promotes induction of ACF by an as yet undefined mechanism when fed immediately before treatment with DMH. Expand
Structural and functional characterization of pronyl-lysine, a novel protein modification in bread crust melanoidins showing in vitro antioxidative and phase I/II enzyme modulating activity.
Exposing Caco-2 cells for 48 h to either synthetically pronylated albumin or purified pronyl-glycine significantly increased phase II GST activity, thus demonstrating for the first time that "pronylated" proteins as part of bread crust melanoidins act as monofunctional inducers of GST, serving as a functional parameter of an antioxidant, chemopreventive activity in vitro. Expand