Two series of bis[2-(E-2-alkenoylamino)ethyl] disulfides (compds. I) and 2-(E-alkenoylamino)ethyl carbamoylmethyl sulfides (compds. II) were synthesized from 2-trans unsaturated fatty acids (Co: i–C14:1) and cystamine, and their effects on carrageenin-induced paw edema were studied. Several of compds. I and II showed significant anti-edema activity at a dose of 25 mg/kg, i.p. These derivatives were much more potent than the starting materials. The alkene chain length influenced the activity. The compounds (compds. 1-3, 1-8, 11-3 and 11-8) with C8:1 and C13,, fatty acids showed the highest activity in both series. Compounds 1-3 and 11-3 with the C8.1 fatty acid were also effective when administered orally at a dose of 10 mg/kg.