Inhibitory effect of bile salts on the enterohepatic circulation of methotrexate in the unanesthetized rat: Inhibition of methotrexate intestinal absorption

@article{Said2004InhibitoryEO,
  title={Inhibitory effect of bile salts on the enterohepatic circulation of methotrexate in the unanesthetized rat: Inhibition of methotrexate intestinal absorption},
  author={H. Said and D. Hollander},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={16},
  pages={121-124}
}
  • H. Said, D. Hollander
  • Published 2004
  • Chemistry, Medicine
  • Cancer Chemotherapy and Pharmacology
  • SummaryThe effect of conjugated and unconjugated bile salts on the intestinal absorption of methotrexate (MTX) in the unanesthetized rat was investigated using a recycling perfusion technique. We initially determined the general characteristics of MTX absorption in vivo. Absorption of low (0.5 μM) and high (6 μM) concentrations of MTX was linear with time for 60 min perfusion and occurred at rates of 0.2 and 1.65 nmol/100 cm dry length/min, respectively. Absorption of 0.5 μM MTX was pH… CONTINUE READING
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