Inhibitory effect of beta-alanyl-L-histidinato zinc on bone resorption in tissue culture.

@article{Yamaguchi1992InhibitoryEO,
  title={Inhibitory effect of beta-alanyl-L-histidinato zinc on bone resorption in tissue culture.},
  author={Masayoshi Yamaguchi and Yuko Segawa and Noriaki Shimokawa and Naoki Tsuzuike and Eijiro Tagashira},
  journal={Pharmacology},
  year={1992},
  volume={45 5},
  pages={292-300}
}
The inhibitory effect of beta-alanyl-L-histidinato zinc (AHZ) on bone resorption in tissue culture was investigated. Calvaria were removed from weanling rats (3-week-old male) and cultured for periods up to 48 h in Dulbecco's modified Eagle medium (high glucose, 4.5%) supplemented with antibiotics and bovine serum albumin. The experimental cultures contained 10(-7) to 10(-4) mol/l AHZ. The bone-resorbing factors, parathyroid hormone (1-34) (PTH; 10(-7) mol/l), prostaglandin E2 (10(-5) mol/l… CONTINUE READING
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