Inhibitory effect of arazyme on the development of atopic dermatitis-like lesions in BALB/c and Nc/Nga mice.

  title={Inhibitory effect of arazyme on the development of atopic dermatitis-like lesions in BALB/c and Nc/Nga mice.},
  author={In Sik Kim and Na Rae Lee and Seung Yeop Baek and Eun Jeong Kim and Jung Seok Kim and Tae-Sook Jeong and Dong-Ha Shin and Ho-Yong Park and Ji-Sook Lee},
  journal={Molecular medicine reports},
  volume={11 5},
Arazyme is a metalloprotease released by Aranicola proteolyticus that was shown to inhibit cytokine release in HaCaT and endothelial cells. However, the regulatory effects of arazyme in atopic dermatitis remain to be fully understood. In the present study, the anti‑inflammatory effects of arazyme in BALB/c and Nc/Nga mice induced with 2,4‑dinitrochlrobenzene (DNCB) were investigated. BALB/c mice were sensitized with DNCB and were subsequently administered arazyme for 4 weeks either orally… 

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