Inhibitory effect of arazyme on the development of atopic dermatitis-like lesions in BALB/c and Nc/Nga mice.

@article{Kim2015InhibitoryEO,
  title={Inhibitory effect of arazyme on the development of atopic dermatitis-like lesions in BALB/c and Nc/Nga mice.},
  author={In Sik Kim and Na Rae Lee and Seung Yeop Baek and Eun Jeong Kim and Jung Seok Kim and Tae-Sook Jeong and Dong-Ha Shin and Ho-Yong Park and Ji-Sook Lee},
  journal={Molecular medicine reports},
  year={2015},
  volume={11 5},
  pages={
          3995-4001
        }
}
Arazyme is a metalloprotease released by Aranicola proteolyticus that was shown to inhibit cytokine release in HaCaT and endothelial cells. However, the regulatory effects of arazyme in atopic dermatitis remain to be fully understood. In the present study, the anti‑inflammatory effects of arazyme in BALB/c and Nc/Nga mice induced with 2,4‑dinitrochlrobenzene (DNCB) were investigated. BALB/c mice were sensitized with DNCB and were subsequently administered arazyme for 4 weeks either orally… 

Figures from this paper

Suppressive Effect of Arazyme on Neutrophil Apoptosis in Normal and Allergic Subjects
TLDR
The results presented here improve the understanding of neutrophil apoptosis regulation and will facilitate development of drugs for treatment of allergic diseases.
Effects of Angelicae dahuricae Radix on 2, 4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in mice model
TLDR
ADR significantly suppressed AD-like symptoms in BALB/c mice: ADR decreased skin thickness and spleen weight of mice, and down-regulated mRNA expression of IL-4, IL-6 and TNF-α in mouse skin tissue.
Arazyme Suppresses Hepatic Steatosis and Steatohepatitis in Diet-Induced Non-Alcoholic Fatty Liver Disease-Like Mouse Model
TLDR
Dietary supplementation of arazyme for 13 weeks effectively protected hepatic steatosis and steatohepatitis by inhibiting SREBP-1-mediated lipid accumulation and macrophage-mediated inflammation.

References

SHOWING 1-10 OF 20 REFERENCES
The Inhibitory Effect of Duchesnea chrysantha Extract on the Development of Atopic Dermatitis‐like Lesions by Regulating IgE and Cytokine Production in Nc/Nga Mice
TLDR
Results may indicate that DcE attenuates the development of atopic dermatitis‐like lesions by lowering the IgE and inflammatory cytokine levels, and that it is useful in drug development for the treatment of atopy dermatitis.
Arazyme inhibits cytokine expression and upregulates skin barrier protein expression.
TLDR
The inhibitory effect of arazyme on allergic inflammation was investigated by evaluating the alteration of cytokine production and expression of skin barrier proteins in immune and HaCaT human keratinocyte cells and may contribute to the development of a therapeutic drug for the treatment of allergic diseases.
Effect of arazyme on the lipopolysaccharide‑induced inflammatory response in human endothelial cells.
TLDR
Results indicate that arazyme has anti‑inflammatory properties in inflamed endothelial cells and may be useful as a therapeutic agent for inflammatory diseases associated with endothelial Cells.
The role of cytokines/chemokines in the pathogenesis of atopic dermatitis.
TLDR
Fine-tuning of the delicate 4-way balance among Th1, Th2, Th17/22 and T(reg) cells is required for the control of AD.
The Mechanism of a Defective IFN-γ Response to Bacterial Toxins in an Atopic Dermatitis Model, NC/Nga Mice, and the Therapeutic Effect of IFN-γ, IL-12, or IL-18 on Dermatitis1
TLDR
The systemic deficiency in the Th1 response to bacterial stimulation thus leads to a Th2-dominant state and may induce an abnormal cellular immune response in the skin accompanied with an overproduction of IgE and a susceptibility to dermatitis in NC mice.
NC/Nga Mice: A Mouse Model for Atopic Dermatitis
TLDR
It was found that the skin lesions of inbred NC mice were clinically and histologically very similar to human AD when the mice were raised under Conv conditions, but not under SPF conditions, and it was assumed that some kinds of environmental factors might trigger AD-like signs and symptoms in NC mice.
Hepatoprotective effect of Arazyme on CCl4-induced acute hepatic injury in SMP30 knock-out mice.
Animal models for atopic dermatitis: are they relevant to human disease?
Recent findings in mouse models for human atopic dermatitis.
TLDR
This review summarizes some mouse models of AD, particularly focusing on NC mice, together with a novel evaluation system for scratching behavior of mice to help the understanding of researchers.
...
1
2
...