Inhibitory effect of apelin-12 on nocturnal food intake in the rat.

@article{OShea2003InhibitoryEO,
  title={Inhibitory effect of apelin-12 on nocturnal food intake in the rat.},
  author={Marie O'Shea and Michelle J. Hansen and Kazuhiko Tatemoto and Margaret Morris},
  journal={Nutritional neuroscience},
  year={2003},
  volume={6 3},
  pages={163-7}
}
Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake. This study reports for the first time, the effect of apelin-12, one of the most potent apelin peptides, on spontaneous (nocturnal) feeding. Randomised intracerebroventricular injection of 1, 3 and 10 nmol apelin-12 or saline vehicle, 10 min prior to lights out, led to dose-dependent reductions in food intake 2-4 h after injection (n = 7; p < 0.05). This suggests that… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…