Inhibitory effect of apelin-12 on nocturnal food intake in the rat.

  title={Inhibitory effect of apelin-12 on nocturnal food intake in the rat.},
  author={Marie O'Shea and Michelle J. Hansen and Kazuhiko Tatemoto and Margaret Morris},
  journal={Nutritional neuroscience},
  volume={6 3},
Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake. This study reports for the first time, the effect of apelin-12, one of the most potent apelin peptides, on spontaneous (nocturnal) feeding. Randomised intracerebroventricular injection of 1, 3 and 10 nmol apelin-12 or saline vehicle, 10 min prior to lights out, led to dose-dependent reductions in food intake 2-4 h after injection (n = 7; p < 0.05). This suggests that… CONTINUE READING

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