Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities.

@article{Nishimura2004InhibitoryEO,
  title={Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities.},
  author={Yuki Nishimura and Norimitsu Kurata and Eriko Sakurai and Hajime Yasuhara},
  journal={Journal of pharmacological sciences},
  year={2004},
  volume={96 3},
  pages={293-300}
}
The potential for drug-drug interactions mediated by the inhibition of cytochrome P-450 (CYP) were concerned during antituberculosis therapy. However, the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid. In the current study, we examined the inhibitory effects of pyrazinamide and ethionamide, both of which are chemically related to isoniazid, on the CYP-mediated activities in human liver microsomes and compared them to that of isoniazid. No… CONTINUE READING

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However , the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid .
However , the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
These results suggested that pyrazinamide and ethionamide did not seem to cause drug interactions mediated by the inhibition of CYP .
No remarkable effects on any CYP activities were observed by pyrazinamide and ethionamide .
No remarkable effects on any CYP activities were observed by pyrazinamide and ethionamide .
These results suggested that pyrazinamide and ethionamide did not seem to cause drug interactions mediated by the inhibition of CYP .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
However , the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid .
However , the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
In the current study , we examined the inhibitory effects of pyrazinamide and ethionamide , both of which are chemically related to isoniazid , on the CYP - mediated activities in human liver microsomes and compared them to that of isoniazid .
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