Inhibitory effect of antisense aminopeptidase N (APN/CD13) cDNA transfection on the invasive potential of osteosarcoma cells

@article{Kido2003InhibitoryEO,
  title={Inhibitory effect of antisense aminopeptidase N (APN/CD13) cDNA transfection on the invasive potential of osteosarcoma cells},
  author={Akira Kido and Sabine Krueger and Carsten Haeckel and Albert Roessner},
  journal={Clinical & Experimental Metastasis},
  year={2003},
  volume={20},
  pages={585-592}
}
Aminopeptidase N (APN/CD13), a Zn2+-dependent ectopeptidase, is localized on the cell surface and functions as a transmembrane protein. Increased expression and activity of APN have been postulated to correlate with the aggressive behavior of several tumor types. In this study, the osteosarcoma cell line MNNG/HOS was stably transfected with an expression vector capable of expressing the antisense transcript of APN. Four stably transfected clones, the control clones and parental cells were… CONTINUE READING