Inhibitory effect of acetic acid on growth of hyperthermophilic archaeon Pyrococcus furiosus.

@article{Nakashimada1999InhibitoryEO,
  title={Inhibitory effect of acetic acid on growth of hyperthermophilic archaeon Pyrococcus furiosus.},
  author={Yutaka Nakashimada and Koichi Nakae and Naomichi Nishio},
  journal={Journal of bioscience and bioengineering},
  year={1999},
  volume={87 2},
  pages={155-60}
}
The growth inhibition of Pyrococcus furiosus by acetic acid was stronger than that by hydrogen and could be described by a non-competitive inhibition model in which the inhibition constants of undissociated acetic acid, K(p) and n, were estimated to be 0.69 mM (25 mM total acetic acid at pH 6.5; pKa=4.96; 98 degrees C) and 1.0, respectively. In order to reduce the acetic acid inhibition, repeated-batch culturing was performed using a filtration module. This yielded 0.49 g of dry cells l(-1… CONTINUE READING