Inhibitory effect of a cyclic urea derivative on rubella virus replication.

Abstract

1-(4-Morpholinomethyl)-tetrahydro-2(1H)-pyrimidinone (mopyridone) exhibited a marked activity against rubella virus (Judith and RA27/3 strains), a MIC50 value of 0.9 microM and selectivity ratio of 557.7 been found in the case of Judith strain. These data, in addition to the previous ones about its anti-alphavirus effects suggest the compound to be considered as a broad spectrum inhibitor of togavirus replication.

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Cite this paper

@article{Galabov2000InhibitoryEO, title={Inhibitory effect of a cyclic urea derivative on rubella virus replication.}, author={Angel S. Galabov and Zafira Georgieva Mihneva and V Hadjiathanassova and V Zhukovec}, journal={Zeitschrift fur Naturforschung. C, Journal of biosciences}, year={2000}, volume={55 3-4}, pages={292-4} }