Inhibitory effect of a complementary peptide on ulceration in the alkali-injured rabbit cornea.

@article{Haddox2001InhibitoryEO,
  title={Inhibitory effect of a complementary peptide on ulceration in the alkali-injured rabbit cornea.},
  author={Jeffrey L. Haddox and Roswell R. Pfister and Charnell Inglis Sommers and Jeana E. Blalock and Matteo Villain},
  journal={Investigative ophthalmology & visual science},
  year={2001},
  volume={42 12},
  pages={2769-75}
}
PURPOSE Two tripeptide chemoattractants, acetyl-proline-glycine-proline (Ac-PGP) and methyl-proline-glycine-proline (Me-PGP), are the primary triggers for early neutrophil invasion into the alkali-injured cornea. In the present study the effectiveness of a complementary peptide designed to inhibit the PGP chemoattractants (arginine-threonine-arginine [RTR] tetrameric peptide) and an apo A-1 mimicking peptide (5F) was investigated in the alkali-injured rabbit eye. METHODS (L)-RTR tetramer, (D… CONTINUE READING
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