Inhibitory effect of a brain derived peptide preparation on the Ca++-dependent protease, calpain

@article{Wronski2000InhibitoryEO,
  title={Inhibitory effect of a brain derived peptide preparation on the Ca++-dependent protease, calpain},
  author={Robert Wronski and Peter Tompa and Birgit Hutter-Paier and Karl Crailsheim and P{\'e}ter Friedrich and Manfred Windisch},
  journal={Journal of Neural Transmission},
  year={2000},
  volume={107},
  pages={145-157}
}
Overactivated calpain might be a key factor in destruction of cytoskeletal proteins involved in the pathophysiology of ischemia and disorders like Alzheimer's disease. Therapeutic effects imply the possible interference of Cerebrolysin® (Ebewe Arzneimittel, Austria) with these molecular events. In this work several in vitro methods have been applied to investigate the interaction between Cerebrolysin and calpain [Enzyme Commission (EC) number: 3.4.22.17]. A conventional caseinolytic assay… CONTINUE READING
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