Inhibitory effect of a TGFβ receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells

@article{Shinto2010InhibitoryEO,
  title={Inhibitory effect of a TGFβ receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells},
  author={Osamu Shinto and Masakazu Yashiro and Hiroyuki Kawajiri and Kazumasa Shimizu and Toshiyuki Shimizu and Atsushi Miwa and Kimiyoshi Hirakawa},
  journal={British Journal of Cancer},
  year={2010},
  volume={102},
  pages={844 - 851}
}
Background:Gastric cancer cells frequently metastasise, partly because of their highly invasive nature. Transforming growth factor-β (TGF-β) receptor signalling is closely associated with the invasion of cancer cells. The aim of this study was to clarify the effect of a TGF-β receptor (TβR) phosphorylation inhibitor on the invasiveness of gastric cancer cells.Methods:Four gastric cancer cell lines, including two scirrhous-type cell lines and two non-scirrhous-type cell lines, were used. A TβR… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 39 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

TGFbeta in cancer

J Massague
  • Cell 134:
  • 2008
VIEW 14 EXCERPTS
HIGHLY INFLUENTIAL

A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

EMT 2.0: shaping epithelia through collective migration.

  • Current opinion in genetics & development
  • 2009
VIEW 2 EXCERPTS