Inhibitory effect of NPC‐17731 on BK‐induced and antigen‐induced airway reactions in guinea‐pigs

  title={Inhibitory effect of NPC‐17731 on BK‐induced and antigen‐induced airway reactions in guinea‐pigs},
  author={Ikemura and Sasaki and Ohmori},
  journal={Clinical \& Experimental Allergy},
  • Ikemura, Sasaki, Ohmori
  • Published 1 May 1998
  • Biology, Chemistry, Medicine
  • Clinical & Experimental Allergy
Bradykinin (BK) has been suggested to act as a mediator in the airways in inflammatory conditions, such as asthma through the activation of B2‐receptors. NPC‐17731 (D‐Arg0[Hyp3, D‐HypE(trans‐propyl)7, Oic8]BK) has potent antagonistic activity against B2‐receptors without agonistic activity. 
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