Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells.
@article{Cheung1999InhibitoryEO, title={Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells.}, author={Filly Cheung and Yaw L Siow and W Z Chen and K O}, journal={Biochemical pharmacology}, year={1999}, volume={58 10}, pages={ 1665-73 } }
44 Citations
Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP-1) but not in endothelial cells (HUVEC).
- BiologyBiochemical pharmacology
- 2001
Ginkgo biloba extract EGb® 761 increases endothelial nitric oxide production in vitro and in vivo
- BiologyCellular and Molecular Life Sciences
- 2007
Phosphorylation of eNOS at a site typical for Akt was acutely enhanced by treatment with EGb® 761, as was Akt phosphorylation at Ser 478, which represents a putative molecular basis for the protective cardiovascular properties of EGb®, 761.
The leaf extract of Ginkgo Biloba L. suppresses oxidized LDL‐stimulated fibronectin production through an antioxidant action in rat mesangial cells
- Biology, MedicineBritish journal of pharmacology
- 2004
The results suggest that the leaf extract of Ginkgo Biloba L. inhibits the oxLDL‐induced production of fibronectin probably through inhibitory effects on ROS generation and SP‐1 activation in rat mesangial cells.
Effects of Ginkgo biloba Extract on Cultured Human Retinal Pigment Epithelial Cells under Chemical Hypoxia
- BiologyCurrent eye research
- 2013
GBE reduced HIF-1α and VEGF expression in RPE cells cultured under chemical hypoxia in vitro as well as enzyme-linked immunosorbent assay (ELISA) results showed.
Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats.
- Biology, ChemistryActa pharmacologica Sinica
- 2003
The modulation of CYP isozymes by GbE and Tan may result in altered metabolism of coadministered drugs.
The standardized Ginkgo biloba extract Egb-761 protects vascular endothelium exposed to oxidized low density lipoproteins.
- BiologyCellular and molecular biology
- 2008
The EGb-761-mediated inhibition of ox-LDL-induced lipoperoxide levels in endothelial cells appears to be an important mechanism by which Ginkgo biloba extract protects endothelial properties.
The effect of Ginkgo biloba extract (EGb 761) on hepatic sinusoidal endothelial cells and hepatic microcirculation in CCl4 rats.
- Biology, MedicineThe American journal of Chinese medicine
- 2004
EGb 761 has protective effect on hepatic endothelial cells and hepatic microcirculation in rats with chronic liver injury induced by CCl4, and the mechanisms may involve its inhibition on ET-1, PAF and lipid peroxidation.
Bilobalide Alleviated Dextran Sulfate Sodium-Induced Experimental Colitis by Inhibiting M1 Macrophage Polarization Through the NF-κB Signaling Pathway
- Biology, MedicineFrontiers in Pharmacology
- 2020
Results indicated that administration of bilobalide improved experimental colitis via inhibition of M1 macrophage polarization through the NF-κB signaling pathway and could act as a potential drug for the treatment of inflammatory bowel disease (IBD) in the not-too-distant future.
Genotype-dependent expression of endothelial nitric oxide synthase (eNOS) and its regulatory proteins in cultured endothelial cells.
- BiologyDNA and cell biology
- 2005
It is demonstrated that endothelial cells maintain genotype-dependent expression even after the deprivation of in vivo environment, suggesting that the cigarette smoking-genotype interaction may require such in vivo conditions to be manifested.
References
SHOWING 1-10 OF 50 REFERENCES
Ginkgo biloba extract (EGb 761): inhibitory effect on nitric oxide production in the macrophage cell line RAW 264.7.
- BiologyBiochemical pharmacology
- 1997
[Protective effects of extract of Ginkgo biloba (EGb) on lysophosphatidylcholine induced damages of vascular endothelial cells in vitro].
- Biology, ChemistryYao xue xue bao = Acta pharmaceutica Sinica
- 1997
It is suggested that EGb afforded protection against BAECs damages induced by LPC and that the protective effect of EGb may be due to anti-lipid peroxidation via free-radical scavenging activity.
Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells.
- Biology, ChemistryFree radical biology & medicine
- 1996
Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage.
- Biology, ChemistryZhongguo yao li xue bao = Acta pharmacologica Sinica
- 1998
GbE protected endothelial cells against LPC-induced damage due to reduction in lipid peroxidation and facilitation of synthesis and/or release of epoprostenol.
Inducible nitric oxide synthase mRNA and activity in glomerular mesangial cells.
- Biology, MedicineKidney international
- 1994
It is suggested that production of NO by glomerular mesangial cells could occur, even when macrophage infiltration is not present, and could, thereby, modulateglomerular and tubular functions within the kidney.
Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite.
- BiologyLaboratory investigation; a journal of technical methods and pathology
- 1996
It is demonstrated that stimulated expression of iNOS is associated with atherosclerosis and that the activity of this enzyme under such conditions preferentially promotes the formation and activity of peroxynitrite.
Nitric oxide synthases in mammals.
- BiologyThe Biochemical journal
- 1994
This review will describe the known biochemical mechanisms involved in the synthesis of NO from L-arginine by the NO synthases and will also describe the nature of these enzymes, their inhibition and their molecular characteristics.
A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages
- Biology, ChemistryFEBS letters
- 1992
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.
- BiologyScience
- 1992
The macrophage enzyme is immunologically induced at the transcriptional level and closely resembles the enzyme in cytokine-treated tumor cells and inflammatory neutrophils.
Inhibition of constitutive and inducible nitric oxide synthase: potential selective inhibition.
- BiologyAnnual review of pharmacology and toxicology
- 1995
This review discusses general inhibition of the NOSs by a variety of agents and then focuses on the possibility of developing agents for specific isoform inhibition.