Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells.

@article{Cheung1999InhibitoryEO,
  title={Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells.},
  author={F. Cheung and Y. Siow and W. Z. Chen and O K.},
  journal={Biochemical pharmacology},
  year={1999},
  volume={58 10},
  pages={
          1665-73
        }
}
Excessive production of nitric oxide (NO) may have cytotoxic effects through the formation of peroxynitrite with superoxide. The extract of Ginkgo biloba leaves (EGb) has been demonstrated to be a potent scavenger of free radicals. Although EGb has been shown recently to inhibit NO production in macrophages, its effect on NO production in endothelial cells is largely unknown. The objective of this study was to elucidate the mechanism by which EGb affects NO production in a human endothelial… Expand
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Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP-1) but not in endothelial cells (HUVEC).
TLDR
Investigation of the effects of several active EGb components on iNOS-mediated NO production in macrophages derived from a human monocytic cell line (THP-1) and in human umbilical vein endothelial cells (HUVEC) suggest that ginkgolide A, ginkGolide B, and bilobalide may contribute to the selective inhibitory effect of EGb on eNOS expression without affecting eNos-mediated No production. Expand
Ginkgo biloba extract EGb® 761 increases endothelial nitric oxide production in vitro and in vivo
TLDR
Phosphorylation of eNOS at a site typical for Akt was acutely enhanced by treatment with EGb® 761, as was Akt phosphorylation at Ser 478, which represents a putative molecular basis for the protective cardiovascular properties of EGb®, 761. Expand
The leaf extract of Ginkgo Biloba L. suppresses oxidized LDL‐stimulated fibronectin production through an antioxidant action in rat mesangial cells
TLDR
The results suggest that the leaf extract of Ginkgo Biloba L. inhibits the oxLDL‐induced production of fibronectin probably through inhibitory effects on ROS generation and SP‐1 activation in rat mesangial cells. Expand
Effects of Ginkgo biloba Extract on Cultured Human Retinal Pigment Epithelial Cells under Chemical Hypoxia
TLDR
GBE reduced HIF-1α and VEGF expression in RPE cells cultured under chemical hypoxia in vitro as well as enzyme-linked immunosorbent assay (ELISA) results showed. Expand
Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats.
TLDR
The modulation of CYP isozymes by GbE and Tan may result in altered metabolism of coadministered drugs. Expand
The standardized Ginkgo biloba extract Egb-761 protects vascular endothelium exposed to oxidized low density lipoproteins.
TLDR
The EGb-761-mediated inhibition of ox-LDL-induced lipoperoxide levels in endothelial cells appears to be an important mechanism by which Ginkgo biloba extract protects endothelial properties. Expand
The effect of Ginkgo biloba extract (EGb 761) on hepatic sinusoidal endothelial cells and hepatic microcirculation in CCl4 rats.
TLDR
EGb 761 has protective effect on hepatic endothelial cells and hepatic microcirculation in rats with chronic liver injury induced by CCl4, and the mechanisms may involve its inhibition on ET-1, PAF and lipid peroxidation. Expand
Bilobalide Alleviated Dextran Sulfate Sodium-Induced Experimental Colitis by Inhibiting M1 Macrophage Polarization Through the NF-κB Signaling Pathway
TLDR
Results indicated that administration of bilobalide improved experimental colitis via inhibition of M1 macrophage polarization through the NF-κB signaling pathway and could act as a potential drug for the treatment of inflammatory bowel disease (IBD) in the not-too-distant future. Expand
Genotype-dependent expression of endothelial nitric oxide synthase (eNOS) and its regulatory proteins in cultured endothelial cells.
TLDR
It is demonstrated that endothelial cells maintain genotype-dependent expression even after the deprivation of in vivo environment, suggesting that the cigarette smoking-genotype interaction may require such in vivo conditions to be manifested. Expand
Chemistry and Biological Activities of Ginkgo Biloba
ABSTRACT: Ginkgo biloba L. is the solo member of the Ginkgoaceae family, and its leaf extract (EGb) has been clinically used for the treatment of cerebral insufficiency. Several experimental studies… Expand
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