Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells.

@article{Cheung1999InhibitoryEO,
  title={Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells.},
  author={F. Cheung and Y. Siow and W. Z. Chen and O K.},
  journal={Biochemical pharmacology},
  year={1999},
  volume={58 10},
  pages={
          1665-73
        }
}
  • F. Cheung, Y. Siow, +1 author K. O
  • Published 1999
  • Medicine, Chemistry
  • Biochemical pharmacology
  • Excessive production of nitric oxide (NO) may have cytotoxic effects through the formation of peroxynitrite with superoxide. The extract of Ginkgo biloba leaves (EGb) has been demonstrated to be a potent scavenger of free radicals. Although EGb has been shown recently to inhibit NO production in macrophages, its effect on NO production in endothelial cells is largely unknown. The objective of this study was to elucidate the mechanism by which EGb affects NO production in a human endothelial… CONTINUE READING
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    References

    SHOWING 1-10 OF 50 REFERENCES
    Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells.
    • 84
    Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite.
    • 432
    Nitric oxide synthases in mammals.
    • 2,611
    Inhibition of constitutive and inducible nitric oxide synthase: potential selective inhibition.
    • 140