Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats

@article{Tabuchi2005InhibitoryEO,
  title={Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats},
  author={Y. Tabuchi and K. Kawarabayashi and K. Furuhama},
  journal={Agents and Actions},
  year={2005},
  volume={41},
  pages={21-24}
}
  • Y. Tabuchi, K. Kawarabayashi, K. Furuhama
  • Published 2005
  • Medicine
  • Agents and Actions
  • We evaluated the inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on rat gastric mucosal lesions induced by compound 48/80 (C48/80: a mast cell degranulator), in comparison with those of disodium cromoglycate (DSCG: a mast cell stabilizer), LY171883 (a peptidoleukotriene antagonist) and cimetidine (a histamine H2 receptor antagonist). Subcutaneous administration of C48/80 (1 mg/kg) once daily for four consecutive days produced extensive gastric… CONTINUE READING
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