Inhibitory dysfunction in amyotrophic lateral sclerosis: future therapeutic opportunities.


In amyotrophic lateral sclerosis, motor neuron hyperexcitability and inhibitory dysfunction is emerging as a potential causative link in the dysfunction and degeneration of the motoneuronal circuitry that characterizes the disease. Interneurons, as key regulators of excitability, may mediate much of this imbalance, yet we know little about the way in which… (More)
DOI: 10.2217/nmt.15.49


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