Inhibitory coreceptors activated by antigens but not by anti-Ig heavy chain antibodies install requirement of costimulation through CD40 for survival and proliferation of B cells.

@article{Hokazono2003InhibitoryCA,
  title={Inhibitory coreceptors activated by antigens but not by anti-Ig heavy chain antibodies install requirement of costimulation through CD40 for survival and proliferation of B cells.},
  author={Yasuhisa Hokazono and Takahiro Adachi and Matthias R. Wabl and Nobuhiko Tada and Teruo Amagasa and Takeshi Tsubata},
  journal={Journal of immunology},
  year={2003},
  volume={171 4},
  pages={1835-43}
}
Ag-induced B cell proliferation in vivo requires a costimulatory signal through CD40, whereas B cell Ag receptor (BCR) ligation by anti-Ig H chain Abs, such as anti-Ig micro H chain Ab and anti-Ig delta H chain Ab, alone induces proliferation of B cells in vitro, even in the absence of CD40 ligation. In this study, we demonstrate that CD40 signaling is required for survival and proliferation of B cells stimulated by protein Ags in vitro as well as in vivo. This indicates that the in vitro… CONTINUE READING

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