Inhibitory control of neostriatal projection neurons by GABAergic interneurons

  title={Inhibitory control of neostriatal projection neurons by GABAergic interneurons},
  author={Tibor Ko{\'o}s and James M. Tepper},
  journal={Nature Neuroscience},
The basal ganglia are a highly interconnected network of nuclei essential for the modulation and execution of voluntary behavior. The neostriatum is the principal input and one of the principal controllers of the output of the basal ganglia. Neostriatal projection neurons seem to be dynamically and powerfully controlled by GABAergic inputs, but the source(s) and physiological properties of these inputs remain unclear. Here we use paired whole-cell recordings to show that this inhibition derives… 

Functional diversity and specificity of neostriatal interneurons

Ablation of striatal interneurons influences activities of entopeduncular neurons

It is suggested that striatal interneurons expressing substance P receptors are important for motor control mechanisms mediated by the cortico-basal ganglia pathways.

Novel GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons

The synaptic organization of a previously unknown circuit that involves direct nicotinic excitation of several classes of GABAergic interneurons, including neuroptide Y–expressing neurogilaform neurons, is described, and enables cholinergic interneeurons to exert rapid inhibitory control of the activity of projection neurons.

Dual Cholinergic Control of Fast-Spiking Interneurons in the Neostriatum

It is suggested that the nicotinic excitation of FS interneurons may play an important role in translating the effect of the brief behaviorally contingent cessation of firing of the tonically active cholinergic interneeurons to the output neurons of the neostriatum.

GABAergic inhibition in the neostriatum.

Presynaptic Modulation by Somatostatin in the Neostriatum

This work shows, through the use of the paired pulse protocol, that somatostatin (SST) acts presynaptically to regulate GABA release from the terminals interconnecting MSNs.



Cholinergic switching within neocortical inhibitory networks.

Cortical cholinergic activation may reduce some forms of intralaminar inhibition, promote intracolumnar inhibited inhibition, and change the direction of information flow within cortical circuits.

GABAergic circuits of the striatum.

  • H. Kita
  • Biology
    Progress in brain research
  • 1993

Selective Innervation of Neostriatal Interneurons by a Subclass of Neuron in the Globus Pallidus of the Rat

During periods of cortical activation, individual pallidal neurons may influence the activity of GABAergic interneurons of the neostriatum (which are involved in feed-forward inhibition and synchronization of principle neuron activity) while simultaneously patterning neuronal activity in basal ganglia downstream of theNeostriatal neurons.

Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons

It is demonstrated that individual GABAergic interneurons can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at 4–7 Hz, and this GABAergic mechanism is sufficient to synchronize the firing of pyramsidal cells.

Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation

It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo.

Surround inhibition among projection neurons is weak or nonexistent in the rat neostriatum.

The absence of demonstrable IPSPs in these experiments argue against the common view that mutual inhibition among spiny neurons is a central organizing principle of striatal function.