Inhibitory control of neostriatal projection neurons by GABAergic interneurons

@article{Kos1999InhibitoryCO,
  title={Inhibitory control of neostriatal projection neurons by GABAergic interneurons},
  author={Tibor Ko{\'o}s and James M. Tepper},
  journal={Nature Neuroscience},
  year={1999},
  volume={2},
  pages={467-472}
}
The basal ganglia are a highly interconnected network of nuclei essential for the modulation and execution of voluntary behavior. The neostriatum is the principal input and one of the principal controllers of the output of the basal ganglia. Neostriatal projection neurons seem to be dynamically and powerfully controlled by GABAergic inputs, but the source(s) and physiological properties of these inputs remain unclear. Here we use paired whole-cell recordings to show that this inhibition derives… 
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References

SHOWING 1-10 OF 58 REFERENCES
GABAergic circuits of the striatum.
  • H. Kita
  • Biology
    Progress in brain research
  • 1993
Selective Innervation of Neostriatal Interneurons by a Subclass of Neuron in the Globus Pallidus of the Rat
TLDR
During periods of cortical activation, individual pallidal neurons may influence the activity of GABAergic interneurons of the neostriatum (which are involved in feed-forward inhibition and synchronization of principle neuron activity) while simultaneously patterning neuronal activity in basal ganglia downstream of theNeostriatal neurons.
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
TLDR
It is demonstrated that individual GABAergic interneurons can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at 4–7 Hz, and this GABAergic mechanism is sufficient to synchronize the firing of pyramsidal cells.
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
TLDR
It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo.
Surround inhibition among projection neurons is weak or nonexistent in the rat neostriatum.
TLDR
The absence of demonstrable IPSPs in these experiments argue against the common view that mutual inhibition among spiny neurons is a central organizing principle of striatal function.
...
...