Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A.

@article{Gruswitz2007InhibitoryCO,
  title={Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A.},
  author={Franz Gruswitz and Joseph O'Connell and Robert Michael Stroud},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 1},
  pages={42-7}
}
Ammonia conductance is highly regulated. A P(II) signal transduction protein, GlnK, is the final regulator of transmembrane ammonia conductance by the ammonia channel AmtB in Escherichia coli. The complex formed between AmtB and inhibitory GlnK at 1.96-A resolution shows that the trimeric channel is blocked directly by GlnK and how, in response to intracellular nitrogen status, the ability of GlnK to block the channel is regulated by uridylylation/deuridylylation at Y51. ATP and Mg(2+) augment… CONTINUE READING

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