• Medicine
  • Published in
    The Journal of laboratory and…
    1977

Inhibitory and lethal concentrations of 9-beta-D-arabinofuranosyladenine and its hypoxanthine-derivative versus herpes simplex virus, type 1.

@article{Williams1977InhibitoryAL,
  title={Inhibitory and lethal concentrations of 9-beta-D-arabinofuranosyladenine and its hypoxanthine-derivative versus herpes simplex virus, type 1.},
  author={Bradford B. Williams and Esme Joan Bailey and A. Martin Lerner},
  journal={The Journal of laboratory and clinical medicine},
  year={1977},
  volume={89 4},
  pages={
          687-91
        }
}
Minimum inhibitory concentrations of 9-beta-D-arabinofuranosyladenine (ara-A, adenine arabinoside, vidarabine) and a purified preparation of 9-beta-D-arabinofuranosylhypoxanthine (arabinoslhypoxanthine, ara-Hx) at end points of 50% MIC50) and 100% (MIC100) reduction to challenges of approximately 50 p.f.u. of herpes simplex virus, type 1 (HSV-1) were determined in vero renal tissue cultures. Adenosine deaminase is universally present in tissue cultures and serum. These same tests were repeated… CONTINUE READING