Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1.

@article{Fujiyama2009InhibitoryAE,
  title={Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1.},
  author={Tomoyuki Fujiyama and Mayumi Yamada and Mami Terao and Toshio Terashima and Hiroyuki Hioki and Yukiko U. Inoue and Takayoshi Inoue and Norihisa Masuyama and Kunihiko Obata and Yuchio Yanagawa and Yoshiya Kawaguchi and Yo-ichi Nabeshima and Mikio Hoshino},
  journal={Development},
  year={2009},
  volume={136 12},
  pages={2049-58}
}
The cochlear nucleus (CN), which consists of dorsal and ventral cochlear nuclei (DCN and VCN), plays pivotal roles in processing and relaying auditory information to the brain. Although it contains various types of neurons, the origins of the distinct subtypes and their developmental molecular machinery are still elusive. Here we reveal that two basic helix-loop-helix transcription factors play crucial roles in specifying neuron subtypes in the CN. Pancreatic transcription factor 1a (Ptf1a) and… CONTINUE READING
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