Inhibitory activity of a phytochemically characterized fraction from Streptocaulon juventas on lung cancer in nude mice.

  title={Inhibitory activity of a phytochemically characterized fraction from Streptocaulon juventas on lung cancer in nude mice.},
  author={Na Han and Jingyu Yang and Linwei Li and Bin Xiao and Sha Sha and Lequan Tran and Jun Yin and Chunfu Wu},
  journal={Planta medica},
  volume={76 6},
In the present study, a 75% ethanol extract of Streptocaulon juventas (SJ), which had a strong inhibitory effect on the proliferation of human lung A549 adenocarcinoma cells, was subjected to bioassay-guided fractionation. The most active fraction (SJF) was obtained using a macroreticular resin column followed by a silica-gel column. Then its in vivo effect on lung cancer was investigated in athymic nude mice with A549 tumors while its effects on body weight, blood biochemical indicators, and… 

Figures from this paper

Anti-tumor activity of the ethyl acetate fraction from Asparagus cochinchinensis in HepG2-xenografted nude mice
EAF-ACE was found to possess antitumor activities without associated hepatotoxicity and nephrotoxicity, and may be effectively used as a chemopreventive agent.
Chemical characterization and assessment of antioxidant potentiality of Streptocaulon sylvestre Wight, an endangered plant of sub-Himalayan plains of West Bengal and Sikkim
The present study provides a convincing evidence that S. sylvestre methanolic extract not only possess potent antioxidant activity but also can be used as a source of natural bioactive phytochemicals in the future.
Metabolomic Fingerprinting of the Volatiles in Different Parts of Streptocaulon sylvestre
ABSTRACT The phytometabolomic fingerprinting of polar and nonpolar fractions of flower, leaf, stem, and root of Streptocaulon sylvestre obtained by gas chromatography-mass spectrometry (GC-MS) were
Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides
Experimental approaches that could be used to reveal the cancer therapeutic potential of cardiac glycosides in preclinical studies are discussed.
Cardenolide glycosides from root of Streptocaulon juventas.
Periplogenin suppresses the growth of esophageal squamous cell carcinoma in vitro and in vivo by targeting STAT3
It is demonstrated that periplogenin acted as a new STAT3 inhibitor, suppressing the growth of ESCC in vitro and in vivo, providing a basis for its potential application in ESCC treatment and prevention.