Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation.

@article{Irving2002InhibitoryAO,
  title={Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation.},
  author={James A Irving and Sain S Shushanov and Robert N. Pike and Evgenya Y Popova and Dieter Br{\"o}mme and Theresa Helen Taillefer Coetzer and Stephen P. Bottomley and Iaroslava A Boulynko and Sergei A Grigoryev and James C. Whisstock},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 15},
  pages={13192-201}
}
MENT (Myeloid and Erythroid Nuclear Termination stage-specific protein) is a developmentally regulated chromosomal serpin that condenses chromatin in terminally differentiated avian blood cells. We show that MENT is an effective inhibitor of the papain-like cysteine proteinases cathepsins L and V. In addition, ectopic expression of MENT in mammalian cells is apparently sufficient to inhibit a nuclear papain-like cysteine proteinase and prevent degradation of the retinoblastoma protein, a major… CONTINUE READING
42 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…